I enjoy playing my bass guitar with Rocksmith. However I do not use Windows at all and wanted it to work with Kali Linux 2021.2, a Debian 10 Distro.
This is how I got it to work with my audio and Nvidia GeForce RTX 2070
Install crossover bin file
chmod 755 install-crossover-21.0.0.bin
Activate critical 32 bit libraries so that 32 bit games run on 64 bit linux
sudo dpkg –add-architecture i386
sudo apt install nvidia-driver-libs:i386
In Crossover install steam
In Steam install rocksmith and Rocksmith 2014
Run cxdiag – works
Run cxdiag64 – works
Manual Fixes for 32 bit libraries so audio can work perfectly and other things like odbc etc
apt-get install gstreamer1.0-plugins-bad:i386
Change audio to alsa
chmod +x winetricks
set audio to alsa
Run crossover regedit
Run bottle command regedit
Import registry file to bottle
Change driver to alsa
Now configure your steam bottle to use alsa audio drivers for Rocksmith to work.
~/cxoffice/bin/wine –bottle “Steam” winecfg
Configure Rocksmith INI
Enjoy playing your guitar on linux with rocksmith!